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Toxicity studies: Acute
Acute Toxicity Studies evaluate short-term serious adverse effects after clinical and parenteral administration either as a single dose or in multiple doses during 24 hours.
The test uses two mammalian species, including one non-rodent, and provides the following information:
- Potential for acute toxicity in humans
- Potential for toxicity against the target organs
- The time course of drug-induced effects
- An appropriate dosage for multiple-dose toxicity studies
- Species differences in toxicity
Data on acute toxicity can predict the outcome in human overdose and supports Phase III clinical trials.
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OECD 405/OCSPP 870.2400: Acute eye irritation/corrosion
Genetic, Acute -
OECD 402/OCSPP 870.1200: Acute dermal toxicity
Acute -
OECD 403/OCSPP 870.1300: Acute inhalation toxicity
Acute -
OECD 213: Honeybee (apis mellifera), acute oral toxicity test
Acute, Terrestrial -
OECD 214: Honeybee (apis mellifera), acute contact toxicity test
Acute, Terrestrial
