OECD 405/OCSPP 870.2400: Acute eye irritation/corrosion
Genetic, Acute
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Search for common nonclinical studies and assays; customization is possible.
Toxicity studies: Acute
Toxicity studies: Acute
Acute Toxicity Studies evaluate short-term serious adverse effects after clinical and parenteral administration either as a single dose or in multiple doses during 24 hours.
The test uses two mammalian species, including one non-rodent, and provides the following information:
- Potential for acute toxicity in humans
- Potential for toxicity against the target organs
- The time course of drug-induced effects
- An appropriate dosage for multiple-dose toxicity studies
- Species differences in toxicity
Data on acute toxicity can predict the outcome in human overdose and supports Phase III clinical trials.
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC. Learn more about our commitment to replacing, reusing and refining nonclinical research models.