Online Catalog

Search for common nonclinical studies and assays; customization is possible.

Model: Anti-tumor efficacy

Model: Anti-tumor efficacy

Anti-tumor efficacy models evaluate the therapeutic efficacy of a specific therapy using human xenograft or murine syngeneic animal models. These models can be used to advance preclinical drug development efforts. For example, a murine model of subcutaneous colorectal adenocarcinoma (CT26) was used to assess the impact of checkpoint blockade by anti-mPD-1, anti-mPD-L1 or anti-mCTLA-4 on established disease. These regimens were moderately responsive, enabling these data to inform downstream rational combination strategies with these agents.

Human and murine tumor models can be used to assess subcutaneous, orthotopic, systemic, and/or metastatic disease and the impact of treatment on disease progression.

Molecule or Product Type

Small Molecule, Biologics

Models

Mouse, Human

Regulatory

IND & CTA, FIH

Industry Market

Pharma

Phase

Discovery