OECD 405/OCSPP 870.2400: Acute eye irritation/corrosion
Genetic, Acute
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A collection of nonclinical studies & assays; customization is possible.
Toxicity studies: Acute (single dose)
Toxicity studies: Acute (single dose)
Acute toxicity is produced by an active ingredient when administered in one or more doses during a maximum period of 24 hours. The test uses two mammalian species, including one nonrodent.
The objective is to identify doses causing no adverse effect and doses causing major, life-threatening toxicity.
Information obtained from single-dose studies is useful in choosing doses for repeat-dose studies, providing preliminary identification of target organs of toxicity.
Acute toxicity studies may also aid in the selection of starting doses for Phase I human studies and provide information relevant to acute overdosing in humans.
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC. Learn more about our commitment to replacing, reusing and refining nonclinical research models.