OECD 405/OCSPP 870.2400: Acute eye irritation/corrosion
Genetic, Acute
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Search for common nonclinical studies and assays; customization is possible.
Toxicity studies: Acute (single dose)
Toxicity studies: Acute (single dose)
Acute toxicity is produced by an active ingredient when administered in one or more doses during a maximum period of 24 hours. The test uses two mammalian species, including one nonrodent.
The objective is to identify doses causing no adverse effect and doses causing major, life-threatening toxicity.
Information obtained from single-dose studies is useful in choosing doses for repeat-dose studies, providing preliminary identification of target organs of toxicity.
Acute toxicity studies may also aid in the selection of starting doses for Phase I human studies and provide information relevant to acute overdosing in humans.
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