OECD 405/OCSPP 870.2400: Acute eye irritation/corrosion
Labcorp is a leading global life sciences company that includes contract research and developmental services to the pharmaceutical, medical technology, crop protection and chemical industries.
Acute toxicity is produced by an active ingredient when administered in one or more doses during a maximum period of 24 hours. The test uses two mammalian species, including one nonrodent.
The objective is to identify doses causing no adverse effect and doses causing major, life-threatening toxicity.
Information obtained from single-dose studies is useful in choosing doses for repeat-dose studies, providing preliminary identification of target organs of toxicity.
Acute toxicity studies may also aid in the selection of starting doses for Phase I human studies and provide information relevant to acute overdosing in humans.